Back to search

Article

Engineered Feedback Employing Natural Hypoxia-Responsive Factors Enhances Synthetic Hypoxia Biosensors

2024-09-30

Abstract excerpt

<h4>ABSTRACT</h4> DNA-based hypoxia biosensors conditionally express a gene of interest when a cell is in a state of inadequate oxygen supply, which is a feature of several acute and chronic diseases. These biosensors can be deployed in engineered cells to study or treat disease. Although the central mediators of hypoxia responsiveness have been characterized, the dynamics of this response are generally less unde...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c8d35d13-5abb-5bb1-9813-36d0b90ca636
DOI
10.1101/2024.09.28.615614
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Engineered Feedback Employing Natural Hypoxia-Responsive Factors Enhances Synthetic Hypoxia BiosensorsDOI 10.1101/2024.09.28.615614
Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian CellsSemantic proximity
Negative feedback confers mutational robustness in yeast transcription factor regulation.Semantic proximity
Paradoxical gene regulation explained by competition for genomic sitesSemantic proximity
Synthetic gene circuits enable systems-level biosensor discovery at the host-microbe interfaceSemantic proximity
Conserved responses to oxygen deprivation.Semantic proximity
A general strategy to engineer high-performance mammalian Whole-Cell BiosensorsSemantic proximity
Multiplexing Engineered Receptors for Multiparametric Evaluation of Environmental LigandsSemantic proximity
Nonmonotone invasion landscape by noise-aware control of metastasis activator levelsSemantic proximity
Noise and kinetics of LuxR positive feedback loops.Semantic proximity
Structure-guided engineering of a fast genetically encoded sensor for real-time H <sub>2</sub> O <sub>2</sub> monitoringSemantic proximity
TuNR: Orthogonal Control of Mean and Variability of Endogenous Genes in a Human Cell LineSemantic proximity
Design of novel synthetic promoters to tune gene expression in T cellsSemantic proximity
Select a neighboring publication to make it the new centre.