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Article

Negative feedback buffers effects of regulatory variants.

Molecular systems biology - 29 Jan 2015

Bader Daniel M, Wilkening Stefan, Lin Gen, Tekkedil Manu M, Dietrich Kim, Steinmetz Lars M, Gagneur Julien

Abstract excerpt

Mechanisms conferring robustness against regulatory variants have been controversial. Previous studies suggested widespread buffering of RNA misexpression on protein levels during translation. We do not find evidence that translational buffering is common. Instead, we find extensive buffering at the level of RNA expression, exerted through negative feedback regulation acting in trans, which reduces the effect of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25634765
DOI: 10.15252/msb.20145844
PMCID: PMC4332157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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