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Article

Negative feedback buffers effects of regulatory variants.

Molecular systems biology - 29 Jan 2015

Bader Daniel M, Wilkening Stefan, Lin Gen, Tekkedil Manu M, Dietrich Kim, Steinmetz Lars M, Gagneur Julien

Abstract excerpt

Mechanisms conferring robustness against regulatory variants have been controversial. Previous studies suggested widespread buffering of RNA misexpression on protein levels during translation. We do not find evidence that translational buffering is common. Instead, we find extensive buffering at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25634765
DOI: 10.15252/msb.20145844
PMCID: PMC4332157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25634765-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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