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Article

Evolutionary potential of transcription factors for gene regulatory rewiring.

Nature ecology & evolution - 1 Oct 2018

Igler Claudia, Lagator Mato, Tkačik Gašper, Bollback Jonathan P, Guet Călin C

Abstract excerpt

Gene regulatory networks evolve through rewiring of individual components-that is, through changes in regulatory connections. However, the mechanistic basis of regulatory rewiring is poorly understood. Using a canonical gene regulatory system, we quantify the properties of transcription factors that determine the evolutionary potential for rewiring of regulatory connections: robustness, tunability and...

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PMID: 30201966
DOI: 10.1038/s41559-018-0651-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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