Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry.

Abstract excerpt

Cells adapt to familiar changes in their environment by activating predefined regulatory programs that establish adaptive gene expression states. These hard-wired pathways, however, may be inadequate for adaptation to environments never encountered before. Here, we reveal evidence for an alternative mode of gene regulation that enables adaptation to adverse conditions without relying on external sensory...

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