Evolutionary design of regulatory control. II. Robust error-correcting feedback increases genetic and phenotypic variability

Abstract excerpt

As systems become more robust against perturbations, they can compensate for greater sloppiness in the performance of their components. That robust compensation reduces the force of natural selection on the system’s components, leading to component decay. The paradoxical coupling of robustness and decay predicts that robust systems evolve cheaper, lower performing components, which accumulate greater mutational ge...

Topics

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• Computer Simulation
• DNA, Circular
• Evolution, Molecular
• Gene Expression
• Gene Regulatory Networks
• Models, Genetic
• Mutation
• Time

Identifiers and source

Literature Corpus work

268f2b54-1197-56ae-8972-1e8f0ec94839

DOI

10.1101/405456