Nature of HLA-associated predisposition to childhood acute lymphoblastic leukemia.

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Article

Nature of HLA-associated predisposition to childhood acute lymphoblastic leukemia.

Leukemia - 1 May 1995

Dorak M T, Owen G, Galbraith I, Henderson N, Webb D, Mills K I, Darke C, Burnett A K

Abstract excerpt

A molecular analysis was carried out in 63 sequentially diagnosed childhood acute lymphoblastic leukemia (ALL) patients and 1011 controls to investigate the homozygosity rate for HLA-DR53. HLA-DR53 is associated with acute myeloblastic leukemia at the protein level, and our previous study has shown its association with early-onset chronic myeloid leukemia only in homozygous form at the DNA level. In the present...

Topics

Adolescent
Adult
Alleles
DNA, Neoplasm
Female
Genes, Recessive
Genotype
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DR Antigens
HLA-DRB4 Chains
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Polymorphism, Restriction Fragment Length

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Reference Values

Source

Open in PubMed

Identifiers

PMID: 7769851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7769851-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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