Article
The human major histocompatibility complex and childhood leukemia: an etiological hypothesis based on molecular mimicry.
Blood cells, molecules & diseases - 1 Jan 2000
Taylor Malcolm, Hussain Adiba, Urayama Kevin, Chokkalingam Anand, Thompson Pamela, Trachtenberg Elizabeth, Buffler Patricia
Abstract excerpt
The extended human major histocompatibility complex (MHC) is a gene-rich region of about 7.6 Mb on chromosome 6, and includes a high proportion of genes involved in the immune response. Among these are the two Human Leukocyte Antigen (HLA) gene clusters, class I and class II, which encode highly polymorphic classical HLA-A, B, C and HLA-DR, DQ and DP genes, respectively. The protein products of the classical HLA...
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