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Novel association of HLA-DQA1 and HLA-DPB1 alleles with acute myeloid leukemia susceptibility in (Central Asian) Kazakhstani population: A case-control study.

Human immunology - 1 Mar 2026

Turganbekova Aida, Burkitbayev Zhandos, Zhanzakova Zhulduz, Baimukasheva Dana, Saduakas Zhazira, Khamitova Didara, Abdrakhmanova Saniya, Masalimov Zhaksylyk, Almawi Wassim Y

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) is a diverse hematological cancer characterized by clonal growth of myeloid precursors in the bone marrow. Although the core genetic pathways involved in AML development are not completely understood, a connection between specific HLA variants and a predisposition to AML, as well as graft-versus-leukemia effects in transplantation, has been observed across various ethnic...

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PMID: 41633310
DOI: 10.1016/j.humimm.2026.111680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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