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Differential distribution of HLA-A, HLA-B, and HLA-DRB1 allele groups in Iranian pediatric and adult patients with acute lymphoblastic leukemia: A case-control study.

Human immunology - 1 Aug 2026

Ghandehari Farzad, Mirzaei Fatemeh, Meri Seppo, Vojdani Reza, Kalantar Kurosh

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Biological differences between pediatric and adult ALL suggest that inherited immunogenetic factors, such as HLA polymorphisms, may influence susceptibility in an age-dependent manner. We evaluated associations between HLA-A, HLA-B, and HLA-DRB1 allele groups and ALL among pediatric and adult populations in Iran. This case-control study...

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PMID: 42242099
DOI: 10.1016/j.humimm.2026.111770

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