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High-Resolution NGS HLA Typing Identifies Specific Class II-Dominant Risk Haplotypes and HLA LD Structure in Acute Lymphoblastic Leukaemia Among Ethnic Kazakhs.

HLA - 1 Jun 2026

Burkitbayev Zhandos, Turganbekova Aida, Zhanzakova Zhulduz, Baimukasheva Dana, Saduakas Zhazira, Khamitova Didara, Abdrakhmanova Saniya, Masalimov Zhaksylyk, Almawi Wassim Y

Abstract excerpt

Acute lymphoblastic leukaemia (ALL) results from the uncontrolled growth of lymphoid progenitors, yet the immunogenetic factors behind this remain poorly understood. A connection between specific HLA alleles, multi-locus haplotypes and ALL predisposition was suggested, with an ethnic component to this association. This retrospective case-control study analysed 137 ALL cases and 350 ethnically-matched controls...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42265862
DOI: 10.1111/tan.70791
PMCID: PMC13250375

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