Article
The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study.
Atherosclerosis - 1 May 2012
Nambi Vijay, Boerwinkle Eric, Lawson Kim, Brautbar Ariel, Chambless Lloyd, Franeschini Nora, North Kari E, Virani Salim S, Folsom Aaron R, Ballantyne Christie M
Abstract excerpt
OBJECTIVE: We evaluated whether the addition of carotid intima media thickness and plaque (CIMT-P), and a single nucleotide polymorphism on chromosome 9p21 (9p21) together improve coronary heart disease (CHD) risk prediction in the ARIC study. METHODS: Ten year CHD risk was estimated using the ARIC coronary risk score (ACRS) alone and in combination with CIMT-P and 9p21 individually and together in White...
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