Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis.

doi:10.1161/ATVBAHA.108.170332

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Article

Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2008

Samani Nilesh J, Raitakari Olli T, Sipilä Kalle, Tobin Martin D, Schunkert Heribert, Juonala Markus, Braund Peter S, Erdmann Jeanette, Viikari Jorma, Moilanen Leena, Taittonen Leena, Jula Antti, Jokinen Eero, Laitinen Tomi, Hutri-Kähönen Nina, Nieminen Markku S, Kesäniemi Y Antero, Hall Alistair S, Hulkkonen Janne, Kähönen Mika, Lehtimäki Terho

Abstract excerpt

BACKGROUND: Genome-wide association studies have recently identified a locus on chromosome 9p21 that influences risk of coronary artery disease (CAD). The effect of the locus on early markers of atherosclerosis is unknown. We examined its association with carotid intima-media thickness (CIMT) and brachial flow-mediated dilatation (FMD). METHODS AND RESULTS: We genotyped 2277 individuals, age 24 to 39 years, from...

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PMID: 18599798
DOI: 10.1161/ATVBAHA.108.170332

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