Article
Mutant dihydrofolate reductase-thymidylate synthase genes in pyrimethamine-resistant Plasmodium falciparum with polymorphic chromosome duplications.
Molecular and biochemical parasitology - 1 Aug 1990
Tanaka M, Gu H M, Bzik D J, Li W B, Inselburg J
Abstract excerpt
We have identified dihydrofolate reductase (DHFR) gene point mutations and chromosomal changes in pyrimethamine-resistant mutants selected in vitro of Plasmodium falciparum strain FCR3. A pyrimethamine-resistant derivative of the pyrimethamine-sensitive strain FCR3, FCR3-D8, that had been grown i...
Topics
- Animals
- Base Sequence
- Chromosomes
- DNA, Protozoan
- Drug Resistance
- Karyotyping
- Molecular Sequence Data
- Multigene Family
- Mutation
- Plasmodium falciparum
- Polymorphism, Genetic
- Pyrimethamine
- Sensitivity and Specificity
- Tetrahydrofolate Dehydrogenase
- Thymidylate Synthase