Article
Sequence variations in the Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene and their relationship with pyrimethamine resistance.
Molecular and biochemical parasitology - 1 May 1998
de Pécoulas P E, Tahar R, Ouatas T, Mazabraud A, Basco L K
Abstract excerpt
The gene encoding dihydrofolate reductase-thymidylate synthase of the human malaria parasite, Plasmodium vivax, was isolated by polymerase chain reaction from genomic DNA and cloned. The sequences of the dihydrofolate reductase domain of 30 clinical isolates originating from various geographic ar...
Topics
- Amino Acid Sequence
- Animals
- Antimalarials
- Base Sequence
- DNA, Protozoan
- Drug Resistance
- Folic Acid Antagonists
- Genetic Variation
- Molecular Sequence Data
- Plasmodium vivax
- Point Mutation
- Polymerase Chain Reaction
- Pyrimethamine
- Sequence Alignment
- Tetrahydrofolate Dehydrogenase