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Article

In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductase.

Antimicrobial agents and chemotherapy - 1 Apr 2001

Reynolds M G, Oh J, Roos D S

Abstract excerpt

Pyrimethamine is a potent inhibitor of dihydrofolate reductase and is widely used in the treatment of opportunistic infections caused by the protozoan parasite Toxoplasma gondii. In order to assess the potential role of dhfr sequence polymorphisms in drug treatment failures, we examined the dhfr-ts genes of representative isolates for T. gondii virulence types I, II, and III. These strains exhibit differences in...

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Identifiers

PMID: 11257045
DOI: 10.1128/AAC.45.4.1271-1277.2001
PMCID: PMC90454

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Source receipt: pubmed, retrieved 7 Sept 2026.

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