Article
Pyrimethamine resistant mutations in Plasmodium falciparum.
Molecular and biochemical parasitology - 1 Jun 1992
Thaithong S, Chan S W, Songsomboon S, Wilairat P, Seesod N, Sueblinwong T, Goman M, Ridley R, Beale G
Abstract excerpt
Three mutations in Plasmodium falciparum yielding increased resistance to pyrimethamine were obtained following treatment with chemical mutagens and selection in presence of pyrimethamine. From parasite clone TM4/8.2 a mutant, TM4/8.2/4.1, was produced which raised pyrimethamine resistance about...
Topics
- Animals
- Base Sequence
- Drug Resistance
- Humans
- Malaria, Falciparum
- Molecular Sequence Data
- Multienzyme Complexes
- Mutagenesis
- Mutation
- Oligodeoxyribonucleotides
- Plasmodium falciparum
- Polymerase Chain Reaction
- Pyrimethamine
- Tetrahydrofolate Dehydrogenase
- Thymidylate Synthase