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Article

Dihydrofolate reductase mutations and chromosomal changes associated with pyrimethamine resistance of Plasmodium falciparum.

Molecular and biochemical parasitology - 1 Feb 1990

Tanaka M, Gu H M, Bzik D J, Li W B, Inselburg J W

Abstract excerpt

The nucleotide sequence of the dihydrofolate reductase-thymidylate synthase (DHFR-TS) gene in pyrimethamine-resistant (PyrR) mutants of Plasmodium falciparum selected in vitro was examined to determine if specific mutations in DHFR were associated with drug resistance. We analysed the sequence of...

Topics

Animals
Base Sequence
Chromosomes
Drug Resistance
Electrophoresis, Agar Gel
Molecular Sequence Data
Mutation
Plasmodium falciparum
Polymerase Chain Reaction
Polymorphism, Genetic
Pyrimethamine
Tetrahydrofolate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2406591
DOI: 10.1016/0166-6851(90)90015-e

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2406591-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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