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Article

Genetic and metabolic analysis of folate salvage in the human malaria parasite Plasmodium falciparum.

Molecular and biochemical parasitology - 1 May 2004

Wang Ping, Nirmalan Niroshini, Wang Qi, Sims Paul F G, Hyde John E

Abstract excerpt

Antifolate drugs that target the biosynthesis and processing of essential folate cofactors are widely used for treatment of chloroquine-resistant falciparum malaria. Salvage of pre-formed folate can strongly compromise the efficacy of these drugs in vitro and the availability of folate from the human host in natural infections also influences therapeutic outcomes. To investigate how different parasite lines...

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Identifiers

PMID: 15287589
DOI: 10.1016/j.molbiopara.2004.01.008

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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