Article
Chromosomal rearrangements and point mutations in the DHFR-TS gene of Plasmodium chabaudi under antifolate selection.
Molecular and biochemical parasitology - 1 Aug 1990
Cowman A F, Lew A M
Abstract excerpt
Selection of the rodent malaria Plasmodium chabaudi with low levels of the antifolate drug pyrimethamine has previously been shown by us to result in duplication of the dihydrofolate reductase-thymidylate synthase (DHFR-TS) gene by a duplication of chromosome 7 and subsequent rearrangements. We h...
Topics
- Animals
- Chromosomes
- Cloning, Molecular
- Drug Resistance
- Malaria
- Mice
- Mice, Inbred BALB C
- Mutation
- Plasmodium
- Plasmodium falciparum
- Polymerase Chain Reaction
- Pyrimethamine
- Restriction Mapping
- Tetrahydrofolate Dehydrogenase
- Thymidylate Synthase