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Article

Transgenic pyrimethamine-resistant plasmodium falciparum reveals transmission-blocking potency of P218, a novel antifolate candidate drug.

International journal for parasitology - 1 Jul 2021

Posayapisit Navaporn, Pengon Jutharat, Prommana Parichat, Shoram Molnipha, Yuthavong Yongyuth, Uthaipibull Chairat, Kamchonwongpaisan Sumalee, Jupatanakul Natapong

Abstract excerpt

Antimalarial drugs capable of targeting multiple parasite stages, particularly the transmissible stages, can be valuable tools for advancing the malaria elimination agenda. Current antifolate drugs such as pyrimethamine can inhibit replicative parasite stages in both humans and mosquitoes, but antifolate resistance remains a challenge. The lack of reliable gametocyte-producing, antifolate-resistant Plasmodium...

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PMID: 33713651
DOI: 10.1016/j.ijpara.2020.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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