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Article

Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.

PLoS neglected tropical diseases - 1 Nov 2013

Ritt Jean-François, Raymond Frédéric, Leprohon Philippe, Légaré Danielle, Corbeil Jacques, Ouellette Marc

Abstract excerpt

BACKGROUND: The human protozoan parasites Leishmania are prototrophic for pyrimidines with the ability of both de novo biosynthesis and uptake of pyrimidines. METHODOLOGY/PRINCIPAL FINDINGS: Five independent L. infantum mutants were selected for resistance to the pyrimidine analogue 5-fluorouracil (5-FU) in the hope to better understand the metabolism of pyrimidine in Leishmania. Analysis of the 5-FU mutants by...

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Identifiers

PMID: 24278495
DOI: 10.1371/journal.pntd.0002564
PMCID: PMC3836990

Genes

DHFR
UPRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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