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Article

The Base Pairing Partner Modulates Alkylguanine Alkyltransferase.

ACS chemical biology - 21 Sept 2018

McKeague Maureen, Otto Claudia, Räz Michael H, Angelov Todor, Sturla Shana J

Abstract excerpt

O6-Alkylguanine DNA adducts are repaired by the suicide enzyme alkylguanine alkyltransferase (AGT). AGT facilitates repair by binding DNA in the minor groove, flipping out the damaged base, and transferring the O6-alkyl group to a cysteine residue in the enzyme's active site. Despite there being significant knowledge concerning the mechanism of AGT repair, there is limited insight regarding how altered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30040894
DOI: 10.1021/acschembio.8b00446

Genes

AGT
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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