Article
Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations.
Nucleic acids research - 1 May 2013
Zhang Fang, Tsunoda Masaru, Suzuki Kaoru, Kikuchi Yuji, Wilkinson Oliver, Millington Christopher L, Margison Geoffrey P, Williams David M, Czarina Morishita Ella, Takénaka Akio
Abstract excerpt
N-nitrosation of glycine and its derivatives generates potent alkylating agents that can lead to the formation of O(6)-carboxymethylguanine (O(6)-CMG) in DNA. O(6)-CMG has been identified in DNA derived from human colon tissue, and its occurrence has been linked to diets high in red and processed meats. By analogy to O(6)-methylguanine, O(6)-CMG is expected to be highly mutagenic, inducing G to A mutations during...
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