Article
Identification of the point mutations in two vaccinia virus nucleoside triphosphate phosphohydrolase I temperature-sensitive mutants and role of this DNA-dependent ATPase enzyme in virus gene expression.
Virology - 1 Feb 1990
Kahn J S, Esteban M
Abstract excerpt
The biological function of the nucleoside triphosphate phosphohydrolase I (NTPase I) enzyme of vaccinia virus is not yet known. In this investigation we have identified the genetic lesion of two temperature-sensitive mutants of vaccinia virus, ts50 and ts36, as single point mutations contained within the 5'615 nucleotides of the NTPase I gene (ts50, G to A at position 131; ts36, C to T at position 556). The point...
Topics
- Base Sequence
- DNA, Viral
- Gene Expression
- Hydroxyurea
- Molecular Sequence Data
- Mutation
- Nucleoside-Triphosphatase
- Phosphoric Monoester Hydrolases
- Temperature
- Vaccinia virus
- Viral Proteins