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Article

Selective modification of adenovirus replication can be achieved through rational mutagenesis of the adenovirus type 5 DNA polymerase.

Journal of virology - 1 Oct 2012

Capella Cristina, Beltejar Michael-John, Brown Caitlin, Fong Vincent, Daddacha Waaqo, Kim Baek, Dewhurst Stephen

Abstract excerpt

Mutations that reduce the efficiency of deoxynucleoside (dN) triphosphate (dNTP) substrate utilization by the HIV-1 DNA polymerase prevent viral replication in resting cells, which contain low dNTP concentrations, but not in rapidly dividing cells such as cancer cells, which contain high levels of dNTPs. We therefore tested whether mutations in regions of the adenovirus type 5 (Ad5) DNA polymerase that interact...

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Identifiers

PMID: 22811532
DOI: 10.1128/JVI.00739-12
PMCID: PMC3457291

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