Article
Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.
Cancer science - 1 May 2012
Yin Ming, Liao Zhongxing, Yuan Xianglin, Guan Xiaoxiang, O'Reilly Michael S, Welsh James, Wang Li-E, Wei Qingyi
Abstract excerpt
Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and lung cancer progression. We hypothesized that VEGF polymorphisms may modulate the risk of radiation pneumonitis (RP) in non-small cell lung cancer (NSCLC) patients treated with definitive radiotherapy. We genotyped three potentially functional VEGF single nucleotide polymorphisms (-460 T > C [rs833061], -634 G > C [rs2010963] and...
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