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Article

Benzo[a]pyrene, aflatoxine B₁ and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiology.

PloS one - 1 Jan 2012

Paget Vincent, Lechevrel Mathilde, André Véronique, Goff Jérémie Le, Pottier Didier, Billet Sylvain, Garçon Guillaume, Shirali Pirouz, Sichel François

Abstract excerpt

Mutations in the TP53 gene are the most common alterations in human tumours. TP53 mutational patterns have sometimes been linked to carcinogen exposure. In hepatocellular carcinoma, a specific G>T transversion on codon 249 is classically described as a fingerprint of aflatoxin B(1) exposure. Likewise G>T transversions in codons 157 and 158 have been related to tobacco exposure in human lung cancers. However,...

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Identifiers

PMID: 22319594
DOI: 10.1371/journal.pone.0030921
PMCID: PMC3272023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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