Article
Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens.
Mutation research - 1 Apr 2000
Hussain S P, Harris C C
Abstract excerpt
Mutations of the p53 tumor suppressor gene are found in about 50% of all human cancers. The p53 mutation spectra in these cancers are providing clues to the etiology and molecular pathogenesis of cancer. Recent studies indicate that the p53 protein is involved in several vital cellular functions, such as gene transcription, DNA synthesis and repair, cell cycle arrest, senescence and programmed cell death....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.