p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and cancer risk assessment.

doi:10.1289/ehp.96104s3435

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Article

p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and cancer risk assessment.

Environmental health perspectives - 1 May 1996

Harris C C

Abstract excerpt

Carcinogenesis is a multistage process involving the inappropriate activation of normal cellular genes to become oncogenes, e.g., ras, and the inactivation of other cellular genes called tumor suppressor genes. p53 is the prototypic tumor suppressor gene that is well suited as a molecular link be...

Topics

Animals
DNA Adducts
DNA Repair
Genes, p53
Genetic Predisposition to Disease
Humans
Mutation
Neoplasms
Risk Assessment

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