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Article

TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer.

IARC scientific publications - 1 Jan 2004

Olivier Magali, Hussain S Perwez, Caron de Fromentel Claude, Hainaut Pierre, Harris Curtis C

Abstract excerpt

Among genetic alterations, the activation of proto-oncogenes and inactivation of tumour suppressor genes in affected cells are considered to be the core molecular events that provide a selective growth advantage and clonal expansion during the multistep process of carcinogenesis. The TP53 tumour suppressor gene is mutated in about half of all human cancer cases. The p53 protein modulates multiple cellular...

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PMID: 15055300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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