p53 as a sensor of carcinogenic exposures: mechanisms of p53 protein induction and lessons from p53 gene mutations.

Article

p53 as a sensor of carcinogenic exposures: mechanisms of p53 protein induction and lessons from p53 gene mutations.

Pathologie-biologie - 1 Dec 1997

Hainaut P, Vähäkangas K

Abstract excerpt

The p53 tumor suppressor gene encodes a nuclear phosphoprotein with growth inhibiting properties, which is activated in cell exposed to various forms of DNA damaging stress. The development of human cancer often involves inactivation of this suppressor through various mechanisms, including gene d...

Topics

Biomarkers, Tumor
Carcinogens, Environmental
DNA Damage
Genes, Reporter
Genes, p53
Humans
Models, Molecular
Mutation
Tumor Suppressor Protein p53

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