Article
Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment.
Lung cancer (Amsterdam, Netherlands) - 1 Dec 2001
Hussain S P, Hofseth L J, Harris C C
Abstract excerpt
The p53 tumor suppressor gene is mutated in about half of all human cancer cases. The p53 protein modulates multiple cellular functions, such as gene transcription, DNA synthesis and repair, cell cycle arrest, senescence, and apoptosis. Mutations in the p53 gene can abrogate these functions and may lead to genetic instability and progress to cancer. The molecular archeology of the p53 mutation spectrum generates...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.