Article
Molecular analyses of HLA class II-associated susceptibility to subtypes of autoimmune diseases unique to Asians.
International journal of cardiology - 1 Oct 1998
Nishimura Y, Kanai T, Oiso M, Tabata H, Ito H, Kira J, Chen Y Z, Matsushita S
Abstract excerpt
It is well known that individuals positive for particular HLA-class II alleles show high risks for the development of Takayasu arteritis and other diseases caused by immunological disorders such as autoimmune diseases and allergies. HLA class II molecules present antigenic peptides to CD4+ T cells. Their extensive polymorphism affects the structures of peptides bound to HLA class II molecules to create individual...
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