Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features.

doi:10.1038/modpathol.2012.240

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Article

Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2013

Rosty Christophe, Young Joanne P, Walsh Michael D, Clendenning Mark, Walters Rhiannon J, Pearson Sally, Pavluk Erika, Nagler Belinda, Pakenas David, Jass Jeremy R, Jenkins Mark A, Win Aung Ko, Southey Melissa C, Parry Susan, Hopper John L, Giles Graham G, Williamson Elizabeth, English Dallas R, Buchanan Daniel D

Abstract excerpt

KRAS-mutated carcinomas comprise 35-40% of all colorectal carcinomas but little is known about their characteristics. The aim of this study was to examine the pathological and molecular features of KRAS-mutated colorectal carcinomas and to compare them with other carcinoma subgroups. KRAS mutation testing was performed in 776 incident tumors from the Melbourne Collaborative Cohort Study. O(6)-methylguanine DNA...

Topics

Adult
Aged
Biomarkers, Tumor
Carcinoma
Cell Differentiation
Chi-Square Distribution
Colonic Polyps
Colorectal Neoplasms
DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Modification Methylases

DNA Mutational Analysis

DNA Repair Enzymes

Female

Genetic Predisposition to Disease

Humans

Immunohistochemistry

Kaplan-Meier Estimate

Male

Source

Open in PubMed

Identifiers

PMID: 23348904
DOI: 10.1038/modpathol.2012.240

Genes

KRAS
MGMT
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23348904-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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