Article
Clinicopathological features of mismatch repair protein expression patterns in colorectal cancer.
Pathology, research and practice - 1 Jan 2021
Lee Chung-Ta, Chow Nan-Haw, Chen Yi-Lin, Ho Chung-Liang, Yeh Yu-Min, Lin Shao-Chieh, Lin Peng-Chan, Lin Bo-Wen, Chu Chien-An, Tsai Hung-Wen, Lee Jenq-Chang
Abstract excerpt
Microsatellite instability (MSI) is reflective of a deficient mismatch repair (dMMR) system, which is mostly associated with the methylation of mismatch repair (MMR) genes and BRAF mutations in sporadic colorectal cancers (CRCs). We performed a retrospective study to analyze the clinicopathological features of dMMR CRCs and their association with the BRAF V600E mutation. The incidence of dMMR CRCs in our cohort...
Topics
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Colorectal Neoplasms
- DNA Mismatch Repair
- DNA Repair Enzymes
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Microsatellite Instability