Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA demethylation in normal colon tissue predicts predisposition to multiple cancers.

Oncogene - 29 Nov 2012

Kamiyama H, Suzuki K, Maeda T, Koizumi K, Miyaki Y, Okada S, Kawamura Y J, Samuelsson J K, Alonso S, Konishi F, Perucho M

Abstract excerpt

Some colon cancer (CC) patients present synchronous cancers at diagnosis and others develop metachronous neoplasms, but the risk factors are unclear for non-hereditary CC. We showed previously that global DNA demethylation increased with aging and correlated with genomic damage in CC, and we show now that preferentially associates to CCs with wild-type p53. This study aimed to elucidate the extent of DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Colon
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Long Interspersed Nucleotide Elements

Share to Neoplasms

Share to Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 22310288
DOI: 10.1038/onc.2011.652
PMCID: PMC4013778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA demethylation in normal colon tissue predicts predisposition to multiple cancers.PMID 22310288Read ↗

Oxidative DNA damage induces hypomethylation in a compromised base excision repair colorectal tumourigenesis.Semantic proximity Read ↗

A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal CancerSemantic proximity Read ↗

Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations.Semantic proximity Read ↗

DNA repair capacity and response to treatment of colon cancer.Semantic proximity Read ↗

Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction.Semantic proximity Read ↗

Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.Semantic proximity Read ↗

The accumulation of DNA demethylation in Sat α in normal gastric tissues with Helicobacter pylori infection renders susceptibility to gastric cancer in some individuals.Semantic proximity Read ↗

Field cancerization in the colon: a role for aberrant DNA methylation?Semantic proximity Read ↗

Promoter methylation, transcription, and retrotransposition of LINE-1 in colorectal adenomas and adenocarcinomasSemantic proximity Read ↗

LINE-1 hypomethylation is not a common event in preneoplastic stages of gastric carcinogenesisSemantic proximity Read ↗

Epigenetic regulation of human DCLK-1 gene during colon-carcinogenesis: clinical and mechanistic implicationsSemantic proximity Read ↗

Genetic analysis of multiple synchronous lesions of the colon adenoma–carcinoma sequenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.