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Article

LINE-1 hypomethylation is not a common event in preneoplastic stages of gastric carcinogenesis

30 Jun 2017

Abstract excerpt

LINE-1 hypomethylation is widely accepted as marker for global genomic DNA hypomethylation, which is a frequent event in cancer. The aim of the study was to evaluate LINE-1 methylation status at different stages of gastric carcinogenesis and evaluate its prognostic potential in clinical settings. LINE-1 methylation was analyzed in 267 tissue samples by bisulfite pyrosequencing including primary colorectal cancer...

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PMID: 28684753
DOI: 10.1038/s41598-017-05143-0

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