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Article

Oxidative DNA damage induces hypomethylation in a compromised base excision repair colorectal tumourigenesis.

British journal of cancer - 14 Mar 2017

Furlan Daniela, Trapani Davide, Berrino Enrico, Debernardi Carla, Panero Mara, Libera Laura, Sahnane Nora, Riva Cristina, Tibiletti Maria Grazia, Sessa Fausto, Sapino Anna, Venesio Tiziana

Abstract excerpt

BACKGROUND: A compromised base excision repair (BER) promotes carcinogenesis by accumulating oxidative DNA-damaged products as observed in MUTYH-associated polyposis, a hereditary colorectal cancer syndrome marked by adenomas and cancers with an accumulation of 8-oxoguanine. Remarkably, DNA global demethylation has been shown to be mediated by BER, suggesting a relevant interplay with early colorectal...

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Source

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Identifiers

PMID: 28141798
DOI: 10.1038/bjc.2017.9
PMCID: PMC5355935

Genes

MUTYH
KRAS
MET
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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