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Article

Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction.

Clinical epigenetics - 9 Aug 2021

Debernardi Carla, Libera Laura, Berrino Enrico, Sahnane Nora, Chiaravalli Anna Maria, Laudi Cristiana, Berselli Mattia, Sapino Anna, Sessa Fausto, Venesio Tiziana, Furlan Daniela

Abstract excerpt

BACKGROUND: Aberrant DNA hypomethylation of the long interspersed nuclear elements (LINE-1 or L1) has been recognized as an early event of colorectal transformation. Simultaneous genetic and epigenetic analysis of colorectal adenomas may be an effective and rapid strategy to identify key biological features leading to accelerated colorectal tumorigenesis. In particular, global and/or intragenic LINE-1...

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Identifiers

PMID: 34372923
DOI: 10.1186/s13148-021-01135-0
PMCID: PMC8351348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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