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Article

Field cancerization in the colon: a role for aberrant DNA methylation?

13 Jan 2014

Abstract excerpt

Colorectal cancer is the third most common cancer worldwide and arises secondary to the progressive accumulation of genetic and epigenetic alterations in normal colon cells, which results in a polyp-to-cancer progression sequence. It is known that individuals with a personal history of colon adenomas or cancer are at increased risk for metachronous colon neoplasms. One explanation for this increased risk could be...

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Identifiers

PMID: 24760232
DOI: 10.1093/gastro/got039

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