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Article

Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations.

BMC cancer - 27 Jun 2018

Molnár Béla, Galamb Orsolya, Péterfia Bálint, Wichmann Barnabás, Csabai István, Bodor András, Kalmár Alexandra, Szigeti Krisztina Andrea, Barták Barbara Kinga, Nagy Zsófia Brigitta, Valcz Gábor, Patai Árpád V, Igaz Péter, Tulassay Zsolt

Abstract excerpt

BACKGROUND: DNA mutations occur randomly and sporadically in growth-related genes, mostly on cytosines. Demethylation of cytosines may lead to genetic instability through spontaneous deamination. Aims were whole genome methylation and targeted mutation analysis of colorectal cancer (CRC)-related genes and mRNA expression analysis of TP53 pathway genes. METHODS: Long interspersed nuclear element-1 (LINE-1) BS-PCR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29945573
DOI: 10.1186/s12885-018-4609-x
PMCID: PMC6020382

Genes

APC
KRAS
BRAF
CNTN1
CTNNB1
DKK2
EGFR
ERBB4
FMN1
MSH6
NGFR
NRAS
PDGFRA
SDC2
SMAD2
SMAD4
SOX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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