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Article

Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2009

Figueiredo Jane C, Grau Maria V, Wallace Kristin, Levine A Joan, Shen Lanlan, Hamdan Randala, Chen Xinli, Bresalier Robert S, McKeown-Eyssen Gail, Haile Robert W, Baron John A, Issa Jean-Pierre J

Abstract excerpt

BACKGROUND: Global loss of methylated cytosines in DNA, thought to predispose to chromosomal instability and aneuploidy, has been associated with an increased risk of colorectal neoplasia. Little is known about the relationships between global hypomethylation and lifestyle, demographics, dietary measures, and genetic factors. METHODS: Our data were collected as part of a randomized clinical trial testing the...

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Identifiers

PMID: 19336559
DOI: 10.1158/1055-9965.EPI-08-0926
PMCID: PMC2712652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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