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Article

A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer

25 Sept 2012

Abstract excerpt

OBJECTIVE: Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with a poor prognosis. Methylation levels of genomic repeats such as LINE-1 elements have been recognized as independent factors for increased cancer-related mortality. The methylation status of LINE-1 elements in early-onset CRC has not been analyzed previously. DESIGN: We analyzed 343 CRC tissues...

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Share to Chromosomal and Genetic Variations
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

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PMID: 23049789
DOI: 10.1371/journal.pone.0045357

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