Article

Promoter methylation, transcription, and retrotransposition of LINE-1 in colorectal adenomas and adenocarcinomas

2020-05-19

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>LINE-1, Alu, and SVA elements are non-LTR retrotransposons that create approximately one-third of the human genome. The loss of tight control mechanisms on the function of mobile elements has been implicated in many human diseases. The methylation of the CpG islands of the LINE-1 promoter is one of these mechanisms. In this study, we determined the promoter meth...

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Literature Corpus work: 8d8fc188-a60a-5e9d-b77f-bb281fa3bf09
DOI: 10.21203/rs.3.rs-28838/v1

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