Article
Parameters Influencing Baseline HIV-1 Genotypic Tropism Testing Related to Clinical Outcome in Patients on Maraviroc.
PloS one - 1 Jan 2015
Sierra Saleta, Dybowski J Nikolai, Pironti Alejandro, Heider Dominik, Güney Lisa, Thielen Alex, Reuter Stefan, Esser Stefan, Fätkenheuer Gerd, Lengauer Thomas, Hoffmann Daniel, Pfister Herbert, Jensen Björn, Kaiser Rolf
Abstract excerpt
OBJECTIVES: We analysed the impact of different parameters on genotypic tropism testing related to clinical outcome prediction in 108 patients on maraviroc (MVC) treatment. METHODS: 87 RNA and 60 DNA samples were used. The viral tropism was predicted using the geno2pheno[coreceptor] and T-CUP tools with FPR cut-offs ranging from 1%-20%. Additionally, 27 RNA and 28 DNA samples were analysed in triplicate, 43...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Cyclohexanes
- Female
- Genes, Viral
- Genetic Association Studies
- Genotype
- HIV Fusion Inhibitors