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Article

Sex-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity.

Journal of autoimmunity - 1 May 2012

Sawalha Amr H, Wang Lu, Nadig Ajay, Somers Emily C, McCune W Joseph, Hughes Travis, Merrill Joan T, Scofield R Hal, Strickland Faith M, Richardson Bruce

Abstract excerpt

Lupus is less common in men than women, and the reason is incompletely understood. Current evidence indicates that lupus flares when genetically predisposed individuals encounter environmental agents that trigger the disease, and that the environmental contribution is mediated at least in part by T cell DNA demethylation. We hypothesized that lupus disease activity is directly related to total genetic risk and...

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Share to DNA Methylation
Share to Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Lupus Erythematosus, Systemic

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Sex Factors

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 22305513
DOI: 10.1016/j.jaut.2011.11.008
PMCID: PMC3313010

Genes

PRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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