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Article

Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.

Cell - 3 Feb 2012

Tobin David M, Roca Francisco J, Oh Sungwhan F, McFarland Ross, Vickery Thad W, Ray John P, Ko Dennis C, Zou Yuxia, Bang Nguyen D, Chau Tran T H, Vary Jay C, Hawn Thomas R, Dunstan Sarah J, Farrar Jeremy J, Thwaites Guy E, King Mary-Claire, Serhan Charles N, Ramakrishnan Lalita

Abstract excerpt

Susceptibility to tuberculosis is historically ascribed to an inadequate immune response that fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to Mycobacterium marinum can result from either inadequate or excessive acute inflammation. Modulation of the leukotriene A(4) hydrolase (LTA4H) locus, which controls the balance of pro- and anti-inflammatory eicosanoids, reveals two...

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Identifiers

PMID: 22304914
DOI: 10.1016/j.cell.2011.12.023
PMCID: PMC3433720

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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