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Article

The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.

Cell - 5 Mar 2010

Tobin David M, Vary Jay C, Ray John P, Walsh Gregory S, Dunstan Sarah J, Bang Nguyen D, Hagge Deanna A, Khadge Saraswoti, King Mary-Claire, Hawn Thomas R, Moens Cecilia B, Ramakrishnan Lalita

Abstract excerpt

Exposure to Mycobacterium tuberculosis produces varied early outcomes, ranging from resistance to infection to progressive disease. Here we report results from a forward genetic screen in zebrafish larvae that identify multiple mutant classes with distinct patterns of innate susceptibility to Mycobacterium marinum. A hypersusceptible mutant maps to the lta4h locus encoding leukotriene A(4) hydrolase, which...

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Identifiers

PMID: 20211140
DOI: 10.1016/j.cell.2010.02.013
PMCID: PMC2907082

Genes

LTB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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