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Article

Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2011

Curtis James, Kopanitsa Liliya, Stebbings Emma, Speirs Arran, Ignatyeva Olga, Balabanova Yanina, Nikolayevskyy Vladyslav, Hoffner Sven, Horstmann Rolf, Drobniewski Francis, Nejentsev Sergey

Abstract excerpt

Immunoregulatory eicosanoids have been implicated in protection from mycobacterial infection in cell and animal models. Recently, a study of the zebrafish embryo demonstrated that mutants of the lta4h gene, which encodes the leukotriene A4 hydrolase (LTA4H) enzyme of the eicosanoid pathway, have hypersusceptibility to Mycobacterium marinum infection. It also reported that heterozygosity at the two single...

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Identifiers

PMID: 21112816
DOI: 10.1016/j.tube.2010.11.001
PMCID: PMC3040790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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