Article

Neonatal genetics of gene expression reveal the origins of autoimmune and allergic disease risk

2019-06-27

Abstract excerpt

Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we collected cord blood samples from a birth cohort and mapped expression quantitative trait loci (eQTLs) in resting monocytes and CD4 + T cells as well as in response to lipopolysaccharide (LPS) or phytohemagglutinin (PHA) stimulation, respectively. Cis -eQ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd560116-2490-54c2-bc00-4b7b81f85334
DOI: 10.1101/683086

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neonatal genetics of gene expression reveal the origins of autoimmune and allergic disease riskDOI 10.1101/683086Read

Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk.Semantic proximity Read

17q12-21 risk-variants influence cord blood immune regulation and multitrigger-wheeze.Semantic proximity Read

Tonsillar expression quantitative trait loci verify and expand genetic contributors to childhood atopic diseasesSemantic proximity Read

Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 yearsSemantic proximity Read

Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy OriginsSemantic proximity Read

Expression quantitative trait loci (eQTLs) in human placentas suggest developmental origins of complex diseases.Semantic proximity Read

Different genetic associations of the IgE production among fetus, infancy and childhood.Semantic proximity Read

Cross-genetic determination of maternal and neonatal immune mediators during pregnancy.Semantic proximity Read

DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood.Semantic proximity Read

Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in childrenSemantic proximity Read

Tonsillar expression quantitative trait loci verify and expand genetic contributors to childhood atopic diseasesSemantic proximity Read

The Distinct Immune Nature of the Fetal Inflammatory Response Syndrome Type I and Type IISemantic proximity Read